Spain's Health Professionals Pioneering NAD⁺ and Sirtuin Pathways for Longevity and Healthy Aging

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    NAD⁺ & Sirtuin Pathways: A Health Professional's Guide to Longevity & Healthy Aging

    Spain’s Health Professionals Pioneering NAD⁺ and Sirtuin Pathways for Longevity and Healthy Aging

    Evidence-led innovation in cellular longevity

    Across Spain, leading clinicians, geriatricians, and longevity specialists are integrating cutting-edge research on NAD⁺ metabolism and sirtuin signaling into comprehensive, lifestyle-first programs for healthy aging. With Spain’s robust biomedical ecosystem and the Mediterranean approach to wellness, multidisciplinary teams collaborate to translate peer‑reviewed insights into responsible protocols that may support cellular energy, stress responses, and metabolic balance. This introduction explores how Spanish health professionals are advancing safe, ethical, and personalized strategies while aligning with European guidelines and best practices in longevity medicine.

    What are NAD⁺ and sirtuins—and why they matter

    NAD⁺ is a vital coenzyme involved in mitochondrial function and DNA repair, while sirtuins are a family of enzymes that help regulate cellular repair, metabolic efficiency, and inflammation. Emerging evidence from preclinical and early human studies suggests that approaches aimed at maintaining NAD⁺ levels and sirtuin activity may help support resilience, cognition, and metabolic health as we age. Spanish clinicians emphasize measured, evidence‑based use of lifestyle measures (nutrition, sleep, exercise), regular monitoring, and, where appropriate, carefully evaluated adjuncts—always within regulatory frameworks and individualized care plans.

    Personalized, preventive, and collaborative care in Spain

    From Madrid to Barcelona and Valencia, multidisciplinary teams combine precision nutrition, circadian hygiene, physical activity, and stress management with biomarker‑guided assessments to tailor longevity strategies. By prioritizing transparency, safety, and patient education, Spain’s practitioners foster informed decisions about any NAD⁺‑related interventions, integrating them with proven foundations like the Mediterranean diet. While research continues to evolve, their mission remains clear: empower people to pursue longevity and healthy aging through science‑guided, sustainable habits and clinician‑supervised care.

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    Deeper Clinical Momentum in Spain’s NAD⁺ and Sirtuin–Focused Longevity Care

    Standards, safety, and translational practice

    Spanish clinicians are operationalizing evidence‑based longevity by embedding NAD⁺ and sirtuin insights into structured, ethics‑reviewed pathways that prioritize safety, transparency, and shared decision‑making. Multidisciplinary boards align protocols with European best practices and national oversight, integrating thorough consent, risk stratification, and clear communication about uncertainties. Rather than one‑size‑fits‑all “anti‑aging” claims, teams in Madrid, Barcelona, and Valencia emphasize lifestyle‑first strategies, careful monitoring, and responsible use of adjuncts only when benefits, risks, and patient goals are rigorously assessed within regulatory frameworks.

    Within these programs, foundational pillars—precision nutrition, movement, sleep, and stress resilience—are tailored to support mitochondrial function and cellular repair. Spain’s Mediterranean diet patterns, rich in plants, extra‑virgin olive oil, legumes, and seafood, are frequently highlighted for potential effects on metabolic flexibility and oxidative stress, while structured physical activity and circadian‑aligned routines may help sustain NAD⁺-related pathways. Clinicians underscore that adjunct approaches purported to influence sirtuin activity are evaluated case‑by‑case, remain secondary to proven behaviors, and are integrated only with appropriate screening and follow‑up to safeguard healthy aging goals.

    Personalization hinges on biomarker‑guided care. Spanish longevity teams often combine clinical history with panels tracking metabolic health, inflammation, liver and kidney function, and nutrient status relevant to redox balance and energy metabolism—plus wearable‑derived metrics for sleep, activity, and heart‑rate variability. When used, laboratory proxies and longitudinal trends help clinicians calibrate interventions and detect early signals of benefit or risk. Robust data governance—consent management, secure storage, and GDPR compliance—supports patient trust while enabling iterative, science‑led refinement of NAD⁺ and sirtuin‑informed strategies.

    Spain’s biomedical ecosystem—university hospitals, research institutes, and innovation hubs—continues to expand collaborative projects on cellular longevity, from observational registries to early‑phase clinical research. Educational outreach equips patients with practical literacy on mitochondrial health, recovery, and sustainable habit formation, while clinicians remain vigilant about differentiating promising signals from hype. The overarching aim is consistent: empower individuals to pursue longevity and healthy aging through rigorous science, ethical practice, and personalized, lifestyle‑anchored care that can adapt as high‑quality evidence evolves.

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    Get started with Longevity & Healthy Aging in 7 easy steps!

    • 1. Purchase a kit & create an account.

      Do not forget to buy the personalized nutrition advice and the 3-month Noory subscription to get maximum benefit for Longevity & Healthy Aging.

    • 2. Fill in 3 day food diary & survey

      In the survey select "Longevity & Healthy Aging" as your preferred target group. One FREE target group is included with every testkit.

    • 3. Take a stool sample

      And send it back in the return envelope with a prepaid return label. The return logistics and the laboratory process will generally take 3 to 4 weeks.

    • 4. View your results

      Once your results are uploaded and ready, you will receive an email. Login your dashboard to view all analysis results and recommendations. If you also included the nutrition advice and/or the 3-month Noory subscription in your purchase, these will also be available in your dashboard.

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      5. Noory platform

      If you bought the 3-month Noory subscription, you will receive direct access to personalized food recipes and meal plans on the Noory platform which AUTOMATICALLY take into account your gut microbiome nutrition advice, your allergies, intolerances and nutritional targets.

      Have ultimate real-time flexibility to choose the food recipes that you prefer to cook and eat. Accessible through desktop or mobile device.

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      6. Link your Healthcare Professional (HCP) (optional)

      Both InnerBuddies and Noory are able to provide FREE access to the platform to your healthcare professional. But we need your EXPLICIT consent to do so given all privacy and health regulations. In the InnerBuddies platform you can also download all report sections in PDF format for sharing.

      Noory can also provide HCP access through NooryMed, a remote monitoring platform built for HCP's that allows sharing symptoms, food tracking and also takes into account Food - Drug interactions.

    • retest your gut health

      7. Retest your Gut Microbiome

      After your 3-month Noory subscription has ended, you can perform a new gut microbiome test and hopefully see the desired improvements in your test results. A new gut test will also update your nutrition recommendations and nutritional targets to the Noory platform so that you can start another 3-month improvement process. You can also select a new target group in the InnerBuddies platform if you want to set different objectives for the new 3-month period.

    The InnerBuddies module "Longevity & Healthy Aging" gives you insight in:

    • Gut Microbiome & Short-Chain Fatty Acids (SCFAs)

      SCFAs contribute to anti-inflammation, gut health, and metabolic regulation, all linked to longevity. SCFA's functions as the base mechanism for the other categories. Butyrate gets high weight because of its robust evidence base in inflammation control, gut barrier integrity, and mitochondrial health — all critical for longevity. Propionate pathways are also key, especially for metabolic aging. Acetate is more abundant but generally has broader and more moderate effects; still important, especially as a substrate and signaling molecule.

    • Anti-Inflammatory & Immune Modulation

      Chronic inflammation accelerates aging; these pathways reduce inflammatory markers. Bile acids are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Tryptophan-derived indoles are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Polyamines offer both immunomodulatory and cell-protective benefits, especially in aging tissue. LPS and ammonia detox are supportive pathways—critical but more indirect in their effects.

    • Energy Metabolism & Mitochondrial Health

      Efficient energy metabolism supports cellular function, reduces oxidative stress, and enhances lifespan. TCA cycle and ETC dominate due to their centrality in mitochondrial health, bioenergetics, and ROS control — all of which are strongly linked to aging processes. Fat oxidation (FAO) supports metabolic flexibility, ketogenesis, and fasting states — overlapping with caloric restriction benefits. BCAA metabolism is double-edged: essential for mitochondrial function but excessive levels may promote mTOR activation and insulin resistance — balance is critical.

    • Cellular Repair, DNA Protection & Autophagy

      These pathways regulate DNA repair, cellular stress resistance, and autophagy, essential for longevity. Methionine / glutathione gets top weight for direct protection against oxidative stress, a primary driver of DNA damage. NAD⁺ biosynthesis is central to sirtuin-driven longevity mechanisms and DNA repair. Folate supports DNA stability but has more indirect or cofactor-like effects compared to the above.

    • Caloric Restriction & Fasting Mimicry

      Certain pathways mimic the benefits of fasting and caloric restriction, which are linked to lifespan extension.

    Targeted Recommendations

    The module "Longevity & Healthy Aging" provides you with targeted nuttrition recommendations. Targeted not only on your unique gut microbiome but also targeted on the metabolic pathways that, according to the latest scientific publications, are important for Longevity & Healthy Aging.

    • Personalized on the DNA of your own Gut Microbiome

      Receive nutrition recommendations that according to our self-learning algorithms and our large customer database have the highest impact on your own unique gut microbiome.

    • Approved by our Dieticians

      We use Responsible A.I. techniques and built an algorithm that uses both our own proprietary databases but also the knowledge and experience of our strong dietician team.

    • Actionable

      Nutrition recommendations that you can just buy in your local supermarket. For your convenience, we also provide daily dosage recommendations.

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    Focus on your Biological Age and support Longevity & Healthy Aging - Order the gut test that:

    • Provides a score between 0 and 100 of how your gut microbiome composition is optimized for Biological Age / Longevity / Healthy Aging
    • Provides detailed insight in how you rank for each of the microbial metabolic pathways that have been linked to Biological Age / Longevity / Healthy Aging according to the latest scientific publications
    • Uses a cutting-edge and science-based DNA technology
    • Provides you with nutritional and supplement recommendations based on your microbial results that are specifically optimized to lower your Biological Age and support Longevity & Healthy Aging
    • Is developed by an expert team of dieticians, specialists, and scientists to offer you the most accurate gut microbiome analysis
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    How can InnerBuddies support in reducing your Biological Age and supporting Longevity & Healthy Aging?

    • Improved Digestive Health

      Optimizing the gut microbiome enhances digestion and nutrient absorption, ensuring the body gets vital vitamins and minerals necessary for cellular repair and maintenance, which supports overall health and slows biological aging.

    • Reduced Inflammation

      A balanced gut microbiome helps reduce chronic systemic inflammation—a major driver of aging and age-related diseases—thereby protecting tissues and organs and promoting healthy aging.

    • Enhanced Immune Function

      Gut health directly influences the immune system. Strengthening the microbiome boosts immunity, lowering the risk of infections and age-related immune decline, contributing to longevity.

    • Mental Health and Cognitive Function

      The gut-brain axis connects gut health with brain function. A healthy microbiome can improve mood, reduce anxiety, and support cognitive health, helping maintain mental sharpness with age.

    • Metabolic Health and Weight Management

      Microbiome-based nutrition helps regulate metabolism and blood sugar levels, reducing risks for diabetes and cardiovascular disease, which are linked to accelerated aging.

    • Antioxidant Support and Cellular Repair

      Supplements tailored to the gut microbiome can enhance antioxidant activity and promote cellular repair processes, protecting DNA from damage and slowing biological aging.