Netherlands-Based Health Professionals Advancing NAD⁺ & Sirtuin Pathways for Longevity & Healthy Aging

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    NAD⁺ & Sirtuin Pathways: A Health Professional's Guide to Longevity & Healthy Aging

    Netherlands-Based Health Professionals Advancing NAD⁺ & Sirtuin Pathways for Longevity & Healthy Aging

    Evidence-led cellular health strategies to support resilient aging in the Netherlands

    Across the Netherlands, a growing network of Netherlands-based health professionals—including clinicians, researchers, and allied health experts—is advancing the science of NAD⁺ and Sirtuin pathways to support longevity and healthy aging. From Amsterdam to Rotterdam and Utrecht, these teams apply cutting-edge geroscience to help maintain cellular energy, mitochondrial function, and genomic maintenance, aligning rigorous research with person-centered care and local best practices.

    Grounded in evidence-based methods, they translate peer-reviewed findings on nicotinamide adenine dinucleotide (NAD⁺) and sirtuin signaling into practical frameworks that emphasize lifestyle, nutrition, movement, sleep, and stress resilience. By focusing on metabolic health, mitochondrial efficiency, and cellular resilience, these multidisciplinary teams aim to support healthy lifespan while adhering to ethical standards, safety, and individualized needs.

    Whether you are exploring preventive strategies or seeking collaboration, discover Netherlands initiatives that champion NAD⁺ metabolism and sirtuin pathway research, education, and community programs. Stay connected to updates from longevity clinics, integrative health centers, and academic partners, and learn how optimizing key cellular pathways may help promote healthspan, vitality, and well-being across the lifespan.

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    Translating NAD⁺ Science into Practice Across the Netherlands

    From Dutch research hubs to community care: applying sirtuin insights for everyday health

    Building on the intro above, Netherlands-based health professionals are integrating advances in NAD⁺ metabolism and Sirtuin pathways into pragmatic, person-centered care. Multidisciplinary teams in Amsterdam, Rotterdam, Utrecht, and beyond collaborate to align cellular health insights with real-world priorities—energy, recovery, and resilience—while emphasizing safety, ethics, and informed choice. By combining clinician expertise with coaching, physiotherapy, and nutrition science, they craft structured protocols that support mitochondrial function, redox balance, and metabolic flexibility, always tailored to individual goals and Dutch best practices.

    In these programs, NAD⁺ is examined as a central cofactor for cellular energy production, DNA repair systems, and adaptive stress signaling, while Sirtuin activity (SIRT1–SIRT7) is explored for its roles in chromatin regulation, mitochondrial biogenesis, and inflammation modulation. Teams translate peer-reviewed findings into clinical pathways using validated outcome measures—such as cardiorespiratory fitness markers, sleep quality indices, and metabolic panels—so that progress can be tracked over time. Ongoing education, journal clubs, and cross-institution collaborations help ensure that evolving evidence is interpreted responsibly and contextualized for the Dutch healthcare landscape.

    Practical frameworks typically emphasize lifestyle foundations that may help support healthy aging: nutrient-dense dietary patterns with niacin-containing foods, structured physical activity for mitochondrial efficiency, circadian-aligned sleep routines, and stress-management techniques that favor autonomic balance. Where appropriate, clinicians discuss risk–benefit considerations, potential interactions, and monitoring strategies—prioritizing shared decision-making and adherence to national guidelines. This approach centers on strengthening core pillars of metabolic health and cellular resilience so individuals can make informed choices alongside their care teams.

    For those seeking to engage, Dutch initiatives offer educational workshops, collaborative research opportunities, and community programs focused on longevity and healthspan. Many groups provide updates on registries, pragmatic trials, and implementation projects, with attention to data privacy and ethical governance. By staying connected to local directories of longevity clinics, integrative health centers, and academic partners, professionals and the public can follow emerging work on NAD⁺ and Sirtuin pathway science—and discover pathways to participate in evidence-led efforts that support vitality and well-being across the lifespan.

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    Get started with Longevity & Healthy Aging in 7 easy steps!

    • 1. Purchase a kit & create an account.

      Do not forget to buy the personalized nutrition advice and the 3-month Noory subscription to get maximum benefit for Longevity & Healthy Aging.

    • 2. Fill in 3 day food diary & survey

      In the survey select "Longevity & Healthy Aging" as your preferred target group. One FREE target group is included with every testkit.

    • 3. Take a stool sample

      And send it back in the return envelope with a prepaid return label. The return logistics and the laboratory process will generally take 3 to 4 weeks.

    • 4. View your results

      Once your results are uploaded and ready, you will receive an email. Login your dashboard to view all analysis results and recommendations. If you also included the nutrition advice and/or the 3-month Noory subscription in your purchase, these will also be available in your dashboard.

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      5. Noory platform

      If you bought the 3-month Noory subscription, you will receive direct access to personalized food recipes and meal plans on the Noory platform which AUTOMATICALLY take into account your gut microbiome nutrition advice, your allergies, intolerances and nutritional targets.

      Have ultimate real-time flexibility to choose the food recipes that you prefer to cook and eat. Accessible through desktop or mobile device.

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      6. Link your Healthcare Professional (HCP) (optional)

      Both InnerBuddies and Noory are able to provide FREE access to the platform to your healthcare professional. But we need your EXPLICIT consent to do so given all privacy and health regulations. In the InnerBuddies platform you can also download all report sections in PDF format for sharing.

      Noory can also provide HCP access through NooryMed, a remote monitoring platform built for HCP's that allows sharing symptoms, food tracking and also takes into account Food - Drug interactions.

    • retest your gut health

      7. Retest your Gut Microbiome

      After your 3-month Noory subscription has ended, you can perform a new gut microbiome test and hopefully see the desired improvements in your test results. A new gut test will also update your nutrition recommendations and nutritional targets to the Noory platform so that you can start another 3-month improvement process. You can also select a new target group in the InnerBuddies platform if you want to set different objectives for the new 3-month period.

    The InnerBuddies module "Longevity & Healthy Aging" gives you insight in:

    • Gut Microbiome & Short-Chain Fatty Acids (SCFAs)

      SCFAs contribute to anti-inflammation, gut health, and metabolic regulation, all linked to longevity. SCFA's functions as the base mechanism for the other categories. Butyrate gets high weight because of its robust evidence base in inflammation control, gut barrier integrity, and mitochondrial health — all critical for longevity. Propionate pathways are also key, especially for metabolic aging. Acetate is more abundant but generally has broader and more moderate effects; still important, especially as a substrate and signaling molecule.

    • Anti-Inflammatory & Immune Modulation

      Chronic inflammation accelerates aging; these pathways reduce inflammatory markers. Bile acids are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Tryptophan-derived indoles are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Polyamines offer both immunomodulatory and cell-protective benefits, especially in aging tissue. LPS and ammonia detox are supportive pathways—critical but more indirect in their effects.

    • Energy Metabolism & Mitochondrial Health

      Efficient energy metabolism supports cellular function, reduces oxidative stress, and enhances lifespan. TCA cycle and ETC dominate due to their centrality in mitochondrial health, bioenergetics, and ROS control — all of which are strongly linked to aging processes. Fat oxidation (FAO) supports metabolic flexibility, ketogenesis, and fasting states — overlapping with caloric restriction benefits. BCAA metabolism is double-edged: essential for mitochondrial function but excessive levels may promote mTOR activation and insulin resistance — balance is critical.

    • Cellular Repair, DNA Protection & Autophagy

      These pathways regulate DNA repair, cellular stress resistance, and autophagy, essential for longevity. Methionine / glutathione gets top weight for direct protection against oxidative stress, a primary driver of DNA damage. NAD⁺ biosynthesis is central to sirtuin-driven longevity mechanisms and DNA repair. Folate supports DNA stability but has more indirect or cofactor-like effects compared to the above.

    • Caloric Restriction & Fasting Mimicry

      Certain pathways mimic the benefits of fasting and caloric restriction, which are linked to lifespan extension.

    Targeted Recommendations

    The module "Longevity & Healthy Aging" provides you with targeted nuttrition recommendations. Targeted not only on your unique gut microbiome but also targeted on the metabolic pathways that, according to the latest scientific publications, are important for Longevity & Healthy Aging.

    • Personalized on the DNA of your own Gut Microbiome

      Receive nutrition recommendations that according to our self-learning algorithms and our large customer database have the highest impact on your own unique gut microbiome.

    • Approved by our Dieticians

      We use Responsible A.I. techniques and built an algorithm that uses both our own proprietary databases but also the knowledge and experience of our strong dietician team.

    • Actionable

      Nutrition recommendations that you can just buy in your local supermarket. For your convenience, we also provide daily dosage recommendations.

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    Focus on your Biological Age and support Longevity & Healthy Aging - Order the gut test that:

    • Provides a score between 0 and 100 of how your gut microbiome composition is optimized for Biological Age / Longevity / Healthy Aging
    • Provides detailed insight in how you rank for each of the microbial metabolic pathways that have been linked to Biological Age / Longevity / Healthy Aging according to the latest scientific publications
    • Uses a cutting-edge and science-based DNA technology
    • Provides you with nutritional and supplement recommendations based on your microbial results that are specifically optimized to lower your Biological Age and support Longevity & Healthy Aging
    • Is developed by an expert team of dieticians, specialists, and scientists to offer you the most accurate gut microbiome analysis
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    How can InnerBuddies support in reducing your Biological Age and supporting Longevity & Healthy Aging?

    • Improved Digestive Health

      Optimizing the gut microbiome enhances digestion and nutrient absorption, ensuring the body gets vital vitamins and minerals necessary for cellular repair and maintenance, which supports overall health and slows biological aging.

    • Reduced Inflammation

      A balanced gut microbiome helps reduce chronic systemic inflammation—a major driver of aging and age-related diseases—thereby protecting tissues and organs and promoting healthy aging.

    • Enhanced Immune Function

      Gut health directly influences the immune system. Strengthening the microbiome boosts immunity, lowering the risk of infections and age-related immune decline, contributing to longevity.

    • Mental Health and Cognitive Function

      The gut-brain axis connects gut health with brain function. A healthy microbiome can improve mood, reduce anxiety, and support cognitive health, helping maintain mental sharpness with age.

    • Metabolic Health and Weight Management

      Microbiome-based nutrition helps regulate metabolism and blood sugar levels, reducing risks for diabetes and cardiovascular disease, which are linked to accelerated aging.

    • Antioxidant Support and Cellular Repair

      Supplements tailored to the gut microbiome can enhance antioxidant activity and promote cellular repair processes, protecting DNA from damage and slowing biological aging.