Ireland's Health Professionals Leading NAD⁺ and Sirtuin Pathways for Longevity and Healthy Aging

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    NAD⁺ & Sirtuin Pathways: A Health Professional's Guide to Longevity & Healthy Aging

    Ireland’s Health Professionals Leading NAD⁺ and Sirtuin Pathways for Longevity and Healthy Aging

    Pioneering cellular longevity in Ireland

    Across Dublin, Cork, Galway, and beyond, Ireland’s health professionals are advancing next-generation approaches to longevity by focusing on NAD⁺ replenishment and sirtuin pathways. Integrative clinics and research-led practices translate cutting-edge geroscience into approachable, ethical care frameworks designed to support healthy aging, vitality, and long-term resilience.

    Evidence-informed approaches that prioritize safety and results

    By aligning lifestyle factors—sleep, nutrition, and activity—with emerging insights into mitochondrial function, DNA repair, and cellular stress responses, these clinicians emphasize measured, evidence-informed strategies. Their focus on individualized assessment, biomarker awareness, and multidisciplinary collaboration helps support overall cellular health while maintaining high standards of professional oversight and patient education.

    Why NAD⁺ and sirtuins matter for healthy aging

    NAD⁺ acts as a critical cofactor for sirtuins, enzymes that help regulate metabolic efficiency, inflammation balance, and genomic stability—key pillars of longevity. Ireland’s leaders in this field are helping the public interpret emerging research responsibly, fostering realistic expectations and sustainable habits that can complement standard medical care and promote healthy aging over the long term.

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    Scaling Integrative Longevity Care Across Ireland

    Personalized, biomarker-aware pathways

    Ireland’s health professionals are expanding precise, individualized pathways that consider health histories, lifestyle mapping, and trends in relevant biomarkers to guide supportive strategies for cellular health. Within multidisciplinary teams, clinicians translate geroscience into practical steps that may help maintain NAD⁺ availability and fine-tune sirtuin pathways linked to metabolic efficiency, inflammation balance, and genomic maintenance. By prioritizing measured progress and realistic goals, these programs aim to enhance resilience while staying aligned with evidence-informed standards across Dublin, Cork, Galway, and surrounding regions.

    Lifestyle-first foundations that synergize with NAD⁺ and sirtuin activity

    Core lifestyle pillars—consistent sleep-wake cycles, nutrient-dense eating patterns, hydration, and structured movement—are leveraged to support mitochondrial function and cellular stress responses associated with longevity. Emphasis on high-quality protein, fiber, and phytonutrient-rich foods, together with resistance and aerobic training, can complement the body’s own mechanisms linked to NAD⁺ turnover and sirtuin signaling. Clinicians also integrate stress-modulation practices such as breathwork and mindful movement, encouraging sustainable habits that reinforce healthy aging without overpromising results.

    Clinical governance, safety, and ethical transparency

    Research-led clinics in Ireland underscore robust clinical governance—clear communication, informed decision-making, and monitoring of outcomes—to ensure safety and ethical practice. Collaboration with GPs, pharmacists, nutrition professionals, and physiologists helps create coherent care plans that respect individual needs and medical histories. Transparent education about the state of evidence around NAD⁺, sirtuins, and related longevity topics supports responsible adoption, while adherence to Irish and EU professional standards helps maintain high-quality oversight.

    Access, education, and community engagement in Dublin, Cork, and Galway

    To broaden access, providers are scaling patient education through workshops, telehealth, and community events that unpack the science of healthy aging in clear, actionable terms. Plain-language summaries of emerging findings, myth-busting sessions, and practical checklists help individuals adopt realistic, stepwise changes that complement standard medical care. From city clinics in Dublin, Cork, and Galway to regional practices nationwide, this outreach fosters informed choices about NAD⁺ support and sirtuin pathways, strengthening public literacy and long-term engagement with cellular health and longevity goals.

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    Get started with Longevity & Healthy Aging in 7 easy steps!

    • 1. Purchase a kit & create an account.

      Do not forget to buy the personalized nutrition advice and the 3-month Noory subscription to get maximum benefit for Longevity & Healthy Aging.

    • 2. Fill in 3 day food diary & survey

      In the survey select "Longevity & Healthy Aging" as your preferred target group. One FREE target group is included with every testkit.

    • 3. Take a stool sample

      And send it back in the return envelope with a prepaid return label. The return logistics and the laboratory process will generally take 3 to 4 weeks.

    • 4. View your results

      Once your results are uploaded and ready, you will receive an email. Login your dashboard to view all analysis results and recommendations. If you also included the nutrition advice and/or the 3-month Noory subscription in your purchase, these will also be available in your dashboard.

    • food recipe platform

      5. Noory platform

      If you bought the 3-month Noory subscription, you will receive direct access to personalized food recipes and meal plans on the Noory platform which AUTOMATICALLY take into account your gut microbiome nutrition advice, your allergies, intolerances and nutritional targets.

      Have ultimate real-time flexibility to choose the food recipes that you prefer to cook and eat. Accessible through desktop or mobile device.

    • health professional

      6. Link your Healthcare Professional (HCP) (optional)

      Both InnerBuddies and Noory are able to provide FREE access to the platform to your healthcare professional. But we need your EXPLICIT consent to do so given all privacy and health regulations. In the InnerBuddies platform you can also download all report sections in PDF format for sharing.

      Noory can also provide HCP access through NooryMed, a remote monitoring platform built for HCP's that allows sharing symptoms, food tracking and also takes into account Food - Drug interactions.

    • retest your gut health

      7. Retest your Gut Microbiome

      After your 3-month Noory subscription has ended, you can perform a new gut microbiome test and hopefully see the desired improvements in your test results. A new gut test will also update your nutrition recommendations and nutritional targets to the Noory platform so that you can start another 3-month improvement process. You can also select a new target group in the InnerBuddies platform if you want to set different objectives for the new 3-month period.

    The InnerBuddies module "Longevity & Healthy Aging" gives you insight in:

    • Gut Microbiome & Short-Chain Fatty Acids (SCFAs)

      SCFAs contribute to anti-inflammation, gut health, and metabolic regulation, all linked to longevity. SCFA's functions as the base mechanism for the other categories. Butyrate gets high weight because of its robust evidence base in inflammation control, gut barrier integrity, and mitochondrial health — all critical for longevity. Propionate pathways are also key, especially for metabolic aging. Acetate is more abundant but generally has broader and more moderate effects; still important, especially as a substrate and signaling molecule.

    • Anti-Inflammatory & Immune Modulation

      Chronic inflammation accelerates aging; these pathways reduce inflammatory markers. Bile acids are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Tryptophan-derived indoles are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Polyamines offer both immunomodulatory and cell-protective benefits, especially in aging tissue. LPS and ammonia detox are supportive pathways—critical but more indirect in their effects.

    • Energy Metabolism & Mitochondrial Health

      Efficient energy metabolism supports cellular function, reduces oxidative stress, and enhances lifespan. TCA cycle and ETC dominate due to their centrality in mitochondrial health, bioenergetics, and ROS control — all of which are strongly linked to aging processes. Fat oxidation (FAO) supports metabolic flexibility, ketogenesis, and fasting states — overlapping with caloric restriction benefits. BCAA metabolism is double-edged: essential for mitochondrial function but excessive levels may promote mTOR activation and insulin resistance — balance is critical.

    • Cellular Repair, DNA Protection & Autophagy

      These pathways regulate DNA repair, cellular stress resistance, and autophagy, essential for longevity. Methionine / glutathione gets top weight for direct protection against oxidative stress, a primary driver of DNA damage. NAD⁺ biosynthesis is central to sirtuin-driven longevity mechanisms and DNA repair. Folate supports DNA stability but has more indirect or cofactor-like effects compared to the above.

    • Caloric Restriction & Fasting Mimicry

      Certain pathways mimic the benefits of fasting and caloric restriction, which are linked to lifespan extension.

    Targeted Recommendations

    The module "Longevity & Healthy Aging" provides you with targeted nuttrition recommendations. Targeted not only on your unique gut microbiome but also targeted on the metabolic pathways that, according to the latest scientific publications, are important for Longevity & Healthy Aging.

    • Personalized on the DNA of your own Gut Microbiome

      Receive nutrition recommendations that according to our self-learning algorithms and our large customer database have the highest impact on your own unique gut microbiome.

    • Approved by our Dieticians

      We use Responsible A.I. techniques and built an algorithm that uses both our own proprietary databases but also the knowledge and experience of our strong dietician team.

    • Actionable

      Nutrition recommendations that you can just buy in your local supermarket. For your convenience, we also provide daily dosage recommendations.

    innerbuddies gut microbiome testing

    Focus on your Biological Age and support Longevity & Healthy Aging - Order the gut test that:

    • Provides a score between 0 and 100 of how your gut microbiome composition is optimized for Biological Age / Longevity / Healthy Aging
    • Provides detailed insight in how you rank for each of the microbial metabolic pathways that have been linked to Biological Age / Longevity / Healthy Aging according to the latest scientific publications
    • Uses a cutting-edge and science-based DNA technology
    • Provides you with nutritional and supplement recommendations based on your microbial results that are specifically optimized to lower your Biological Age and support Longevity & Healthy Aging
    • Is developed by an expert team of dieticians, specialists, and scientists to offer you the most accurate gut microbiome analysis
    Start your journey!

    How can InnerBuddies support in reducing your Biological Age and supporting Longevity & Healthy Aging?

    • Improved Digestive Health

      Optimizing the gut microbiome enhances digestion and nutrient absorption, ensuring the body gets vital vitamins and minerals necessary for cellular repair and maintenance, which supports overall health and slows biological aging.

    • Reduced Inflammation

      A balanced gut microbiome helps reduce chronic systemic inflammation—a major driver of aging and age-related diseases—thereby protecting tissues and organs and promoting healthy aging.

    • Enhanced Immune Function

      Gut health directly influences the immune system. Strengthening the microbiome boosts immunity, lowering the risk of infections and age-related immune decline, contributing to longevity.

    • Mental Health and Cognitive Function

      The gut-brain axis connects gut health with brain function. A healthy microbiome can improve mood, reduce anxiety, and support cognitive health, helping maintain mental sharpness with age.

    • Metabolic Health and Weight Management

      Microbiome-based nutrition helps regulate metabolism and blood sugar levels, reducing risks for diabetes and cardiovascular disease, which are linked to accelerated aging.

    • Antioxidant Support and Cellular Repair

      Supplements tailored to the gut microbiome can enhance antioxidant activity and promote cellular repair processes, protecting DNA from damage and slowing biological aging.