Poland's Women in NAD⁺ and Sirtuin Pathways: Advancing Longevity and Healthy Aging

Women’s Health at the Nexus of NAD⁺ and Sirtuin Pathways: Advancing Longevity and Healthy Aging

Poland's Women in NAD⁺ and Sirtuin Pathways: Advancing Longevity and Healthy Aging

Championing cellular vitality and evidence-based longevity science

Across Poland, a new generation of women scientists, clinicians, and biotech founders is illuminating how NAD⁺ metabolism and sirtuin pathways influence healthy aging. From leading labs in Warsaw, Kraków, and Gdańsk to agile startups translating discoveries into tools, these leaders are mapping the connections between cellular energy, DNA repair, inflammation, and metabolic resilience. Their work on SIRT1–SIRT7, mitochondrial function, and the NAD⁺ salvage pathway is helping define data-driven strategies for longevity while elevating Poland’s profile in European geroscience and precision health.

With a focus on rigorous, transparent research, Polish teams are advancing biomarkers of aging, NAD metabolomics, and translational studies that explore how lifestyle, genetics, and cellular stress intersect with PARPs, CD38, and sirtuin activity. Investigational compounds such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), along with pathways impacting SIRT1 and SIRT3, are being examined in preclinical and human research settings to better understand their potential roles in supporting cellular homeostasis and metabolic health. The result is an evidence-led ecosystem that prioritizes reproducibility, safety, and realistic expectations around longevity science.

Driving this momentum are Poland’s women innovators who combine biomedical research with mentorship, international collaboration, and ethical best practices. Supported by university centers and EU-backed initiatives, they are building partnerships that accelerate discovery while shaping public understanding of NAD⁺, sirtuins, and healthy aging. Discover how their leadership is advancing Poland’s role in global longevity research—bridging basic science and real-world impact to promote resilient aging, community health, and a future where cellular vitality is accessible and responsibly pursued.

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Translational Frontiers in NAD⁺ and Sirtuin Research

Turning Polish discoveries into measurable gains for healthy aging

Building on foundational insights into NAD⁺ salvage, SIRT1–SIRT7, and mitochondrial function, Poland’s women leaders are operationalizing rigorous pipelines that link bench science to real-world outcomes. Teams in Warsaw, Kraków, and Gdańsk are harmonizing NAD metabolomics with multi-omics—including proteomics of DNA repair factors and PARP activity—to quantify how cellular stress, CD38-mediated turnover, and metabolic flexibility shift with age. Standardized protocols for biospecimen handling, stable-isotope tracing, and targeted LC–MS empower reproducible readouts of NAD intermediates, sirtuin deacetylase activity, and mitochondrial respiration. By integrating cohort biobanks with longitudinal phenotyping, these projects are defining baseline variance and effect sizes needed to power future longevity trials in a Central European population.

Clinical investigators are designing hypothesis-driven studies that examine how lifestyle inputs—sleep regularity, exercise timing, dietary patterns, and circadian alignment—interact with NAD⁺ pools, SIRT1/SIRT3 signaling, and inflammatory tone. Early-phase trials and mechanistic sub-studies explore the pharmacokinetics and tolerability of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) alongside endpoints such as insulin sensitivity, vascular reactivity, muscle bioenergetics, and DNA damage markers. With pre-registration, transparent analysis plans, and replication across sites, Polish groups emphasize safety, realistic effect sizes, and clinically meaningful outcomes—advancing healthy aging without overstating the current evidence.

On the technology front, women-led startups and academic spinouts are building precision health tools: point-of-care assays for NAD⁺ and CD38 activity, reporter systems for SIRT1–SIRT7, and cloud platforms that fuse wearables-derived digital biomarkers with lab-based metabolomics. Interoperable data models and FAIR principles enable cross-cohort comparisons, while machine learning links biomarker trajectories to outcomes like metabolic resilience and functional capacity. Supported by EU frameworks and national grants, these ventures prioritize quality management, ethical governance, and post-market surveillance, aligning innovation with robust clinical validation.

Equally important is capacity building. Mentorship networks, open-methods workshops, and citizen-science outreach are cultivating a diverse pipeline of Polish scholars fluent in geroscience, biostatistics, and regulatory science. Public-facing resources clarify where NAD⁺ and sirtuin research stands today, what is under active investigation, and how to interpret biomarkers responsibly. Through international collaborations and equitable data-sharing, Poland’s women innovators are shaping a reproducible, evidence-led roadmap for longevity—bridging discovery and clinical implementation to support resilient aging and community health across Europe.

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Get started with Longevity & Healthy Aging in 7 easy steps!

1. Purchase a kit & create an account.
Do not forget to buy the personalized nutrition advice and the 3-month Noory subscription to get maximum benefit for Longevity & Healthy Aging.
2. Fill in 3 day food diary & survey
In the survey select "Longevity & Healthy Aging" as your preferred target group. One FREE target group is included with every testkit.
3. Take a stool sample
And send it back in the return envelope with a prepaid return label. The return logistics and the laboratory process will generally take 3 to 4 weeks.
4. View your results
Once your results are uploaded and ready, you will receive an email. Login your dashboard to view all analysis results and recommendations. If you also included the nutrition advice and/or the 3-month Noory subscription in your purchase, these will also be available in your dashboard.
5. Noory platform
If you bought the 3-month Noory subscription, you will receive direct access to personalized food recipes and meal plans on the Noory platform which AUTOMATICALLY take into account your gut microbiome nutrition advice, your allergies, intolerances and nutritional targets.
Have ultimate real-time flexibility to choose the food recipes that you prefer to cook and eat. Accessible through desktop or mobile device.
6. Link your Healthcare Professional (HCP) (optional)
Both InnerBuddies and Noory are able to provide FREE access to the platform to your healthcare professional. But we need your EXPLICIT consent to do so given all privacy and health regulations. In the InnerBuddies platform you can also download all report sections in PDF format for sharing.
Noory can also provide HCP access through NooryMed, a remote monitoring platform built for HCP's that allows sharing symptoms, food tracking and also takes into account Food - Drug interactions.
7. Retest your Gut Microbiome
After your 3-month Noory subscription has ended, you can perform a new gut microbiome test and hopefully see the desired improvements in your test results. A new gut test will also update your nutrition recommendations and nutritional targets to the Noory platform so that you can start another 3-month improvement process. You can also select a new target group in the InnerBuddies platform if you want to set different objectives for the new 3-month period.

The InnerBuddies module "Longevity & Healthy Aging" gives you insight in:

Gut Microbiome & Short-Chain Fatty Acids (SCFAs)

SCFAs contribute to anti-inflammation, gut health, and metabolic regulation, all linked to longevity. SCFA's functions as the base mechanism for the other categories. Butyrate gets high weight because of its robust evidence base in inflammation control, gut barrier integrity, and mitochondrial health — all critical for longevity. Propionate pathways are also key, especially for metabolic aging. Acetate is more abundant but generally has broader and more moderate effects; still important, especially as a substrate and signaling molecule.
Anti-Inflammatory & Immune Modulation

Chronic inflammation accelerates aging; these pathways reduce inflammatory markers. Bile acids are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Tryptophan-derived indoles are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Polyamines offer both immunomodulatory and cell-protective benefits, especially in aging tissue. LPS and ammonia detox are supportive pathways—critical but more indirect in their effects.
Energy Metabolism & Mitochondrial Health

Efficient energy metabolism supports cellular function, reduces oxidative stress, and enhances lifespan. TCA cycle and ETC dominate due to their centrality in mitochondrial health, bioenergetics, and ROS control — all of which are strongly linked to aging processes. Fat oxidation (FAO) supports metabolic flexibility, ketogenesis, and fasting states — overlapping with caloric restriction benefits. BCAA metabolism is double-edged: essential for mitochondrial function but excessive levels may promote mTOR activation and insulin resistance — balance is critical.
Cellular Repair, DNA Protection & Autophagy

These pathways regulate DNA repair, cellular stress resistance, and autophagy, essential for longevity. Methionine / glutathione gets top weight for direct protection against oxidative stress, a primary driver of DNA damage. NAD⁺ biosynthesis is central to sirtuin-driven longevity mechanisms and DNA repair. Folate supports DNA stability but has more indirect or cofactor-like effects compared to the above.
Caloric Restriction & Fasting Mimicry

Certain pathways mimic the benefits of fasting and caloric restriction, which are linked to lifespan extension.

Targeted Recommendations

The module "Longevity & Healthy Aging" provides you with targeted nuttrition recommendations. Targeted not only on your unique gut microbiome but also targeted on the metabolic pathways that, according to the latest scientific publications, are important for Longevity & Healthy Aging.

Personalized on the DNA of your own Gut Microbiome

Receive nutrition recommendations that according to our self-learning algorithms and our large customer database have the highest impact on your own unique gut microbiome.
Approved by our Dieticians

We use Responsible A.I. techniques and built an algorithm that uses both our own proprietary databases but also the knowledge and experience of our strong dietician team.
Actionable

Nutrition recommendations that you can just buy in your local supermarket. For your convenience, we also provide daily dosage recommendations.

Focus on your Biological Age and support Longevity & Healthy Aging - Order the gut test that:

Provides a score between 0 and 100 of how your gut microbiome composition is optimized for Biological Age / Longevity / Healthy Aging
Provides detailed insight in how you rank for each of the microbial metabolic pathways that have been linked to Biological Age / Longevity / Healthy Aging according to the latest scientific publications
Uses a cutting-edge and science-based DNA technology
Provides you with nutritional and supplement recommendations based on your microbial results that are specifically optimized to lower your Biological Age and support Longevity & Healthy Aging
Is developed by an expert team of dieticians, specialists, and scientists to offer you the most accurate gut microbiome analysis

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How can InnerBuddies support in reducing your Biological Age and supporting Longevity & Healthy Aging?

Improved Digestive Health

Optimizing the gut microbiome enhances digestion and nutrient absorption, ensuring the body gets vital vitamins and minerals necessary for cellular repair and maintenance, which supports overall health and slows biological aging.
Reduced Inflammation

A balanced gut microbiome helps reduce chronic systemic inflammation—a major driver of aging and age-related diseases—thereby protecting tissues and organs and promoting healthy aging.
Enhanced Immune Function

Gut health directly influences the immune system. Strengthening the microbiome boosts immunity, lowering the risk of infections and age-related immune decline, contributing to longevity.

Mental Health and Cognitive Function

The gut-brain axis connects gut health with brain function. A healthy microbiome can improve mood, reduce anxiety, and support cognitive health, helping maintain mental sharpness with age.
Metabolic Health and Weight Management

Microbiome-based nutrition helps regulate metabolism and blood sugar levels, reducing risks for diabetes and cardiovascular disease, which are linked to accelerated aging.
Antioxidant Support and Cellular Repair

Supplements tailored to the gut microbiome can enhance antioxidant activity and promote cellular repair processes, protecting DNA from damage and slowing biological aging.

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