Ireland's Women at the NAD⁺ & Sirtuin Pathways Frontier: Advancing Longevity & Healthy Aging

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    Women’s Health at the Nexus of NAD⁺ and Sirtuin Pathways: Advancing Longevity and Healthy Aging

    Ireland's Women at the NAD⁺ & Sirtuin Pathways Frontier: Advancing Longevity & Healthy Aging

    Championing Irish leadership in cellular resilience, metabolic health, and evidence-based longevity science

    Across Ireland, visionary women scientists, clinicians, and bio-innovators are driving breakthroughs at the intersection of NAD⁺ metabolism and sirtuin pathways, reshaping our understanding of healthy aging and longevity. From molecular biology to clinical translation, these leaders are decoding how cellular energy, epigenetic regulation, and stress responses converge to sustain vitality across the lifespan. Their work puts Ireland on the global map for longevity research, amplifying the impact of women in STEM and accelerating solutions that promote cellular repair, mitochondrial function, and healthy lifespan.

    Leveraging multidisciplinary expertise and Ireland’s collaborative research ecosystem, these teams are advancing rigorous studies on NAD⁺ biosynthesis, sirtuin activation, and biomarkers that track inflammation, proteostasis, and metabolic flexibility. With a commitment to transparency and safety, they explore lifestyle and nutritional synergies alongside research into NAD⁺ precursors (e.g., NMN, NR) while emphasizing robust clinical evidence, ethical frameworks, and equitable access. Their translational approach connects bench science to real-world impact, informing precision strategies for healthy aging without hype.

    As Ireland’s women leaders push the frontier of NAD⁺ & sirtuin biology, they are also building a durable pipeline of talent through mentorship, open science, and industry–academia partnerships. By fostering inclusive innovation, supporting early-career researchers, and engaging the public with clear, evidence-led communication, they are shaping a future where longevity means more years lived in good health. Follow this movement to stay updated on Ireland’s latest breakthroughs in cellular longevity, healthy life expectancy, and women-led discovery that’s setting new standards for global aging research.

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    Deepening Ireland’s Edge in NAD⁺ and Sirtuin Science

    Mechanisms, biomarkers, interventions, and an inclusive ecosystem for healthy aging

    Building on this momentum, Irish teams are mapping the NAD⁺ landscape from the salvage pathway (NAMPT, NRK, NMNAT) to competition with PARPs and CD38, clarifying how redox balance steers sirtuin activity (SIRT1–SIRT7). By probing links among mitochondrial biogenesis, mitophagy, autophagic flux, and epigenetic deacetylation, they illuminate how cellular stress responses, circadian timing, and nutrient sensing co-regulate resilience. These insights help explain patterns in inflammaging, proteostasis, and DNA repair while anchoring longevity claims in measurable biology—not hype.

    Methodologically, women-led consortia in Ireland deploy multi-omics—metabolomics of the NAD metabolome, proteomics of acetyl-lysine targets, and transcriptomic signatures of PGC-1α and stress pathways—alongside high-resolution respirometry, immune profiling, and digital phenotyping. They prioritize rigorous design (preregistration, randomization, appropriate comparators), validated biomarkers (NAD⁺/NADH ratio, inflammatory cytokines, senescence-associated signals), and clinically meaningful endpoints such as physical function, metabolic flexibility, and cognitive resilience, ensuring evidence-based translation.

    Intervention research explores lifestyle and nutritional synergies with NAD⁺ and sirtuin biology: exercise modalities that enhance mitochondrial turnover, protein quality control and autophagy; sleep and circadian alignment; thermic stressors; and dietary patterns emphasizing polyphenols, micronutrient adequacy, and balanced energy intake. In parallel, teams evaluate NAD⁺ precursors such as NR and NMN within ethical, transparent frameworks, focusing on dose–response, safety, and reproducible outcomes while avoiding overclaims and ensuring equitable access.

    Beyond the bench, Irish leaders are shaping an inclusive ecosystem—open data and FAIR standards, mentorship pipelines, industry–academia co-development, and public engagement that demystifies longevity science. By championing women in STEM, promoting reproducibility and regulatory alignment, and creating pathways from discovery to clinical utility, they position Ireland as a European hub for cellular longevity, healthy life expectancy, and responsible innovation open to global collaboration.

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    Get started with Longevity & Healthy Aging in 7 easy steps!

    • 1. Purchase a kit & create an account.

      Do not forget to buy the personalized nutrition advice and the 3-month Noory subscription to get maximum benefit for Longevity & Healthy Aging.

    • 2. Fill in 3 day food diary & survey

      In the survey select "Longevity & Healthy Aging" as your preferred target group. One FREE target group is included with every testkit.

    • 3. Take a stool sample

      And send it back in the return envelope with a prepaid return label. The return logistics and the laboratory process will generally take 3 to 4 weeks.

    • 4. View your results

      Once your results are uploaded and ready, you will receive an email. Login your dashboard to view all analysis results and recommendations. If you also included the nutrition advice and/or the 3-month Noory subscription in your purchase, these will also be available in your dashboard.

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      5. Noory platform

      If you bought the 3-month Noory subscription, you will receive direct access to personalized food recipes and meal plans on the Noory platform which AUTOMATICALLY take into account your gut microbiome nutrition advice, your allergies, intolerances and nutritional targets.

      Have ultimate real-time flexibility to choose the food recipes that you prefer to cook and eat. Accessible through desktop or mobile device.

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      6. Link your Healthcare Professional (HCP) (optional)

      Both InnerBuddies and Noory are able to provide FREE access to the platform to your healthcare professional. But we need your EXPLICIT consent to do so given all privacy and health regulations. In the InnerBuddies platform you can also download all report sections in PDF format for sharing.

      Noory can also provide HCP access through NooryMed, a remote monitoring platform built for HCP's that allows sharing symptoms, food tracking and also takes into account Food - Drug interactions.

    • retest your gut health

      7. Retest your Gut Microbiome

      After your 3-month Noory subscription has ended, you can perform a new gut microbiome test and hopefully see the desired improvements in your test results. A new gut test will also update your nutrition recommendations and nutritional targets to the Noory platform so that you can start another 3-month improvement process. You can also select a new target group in the InnerBuddies platform if you want to set different objectives for the new 3-month period.

    The InnerBuddies module "Longevity & Healthy Aging" gives you insight in:

    • Gut Microbiome & Short-Chain Fatty Acids (SCFAs)

      SCFAs contribute to anti-inflammation, gut health, and metabolic regulation, all linked to longevity. SCFA's functions as the base mechanism for the other categories. Butyrate gets high weight because of its robust evidence base in inflammation control, gut barrier integrity, and mitochondrial health — all critical for longevity. Propionate pathways are also key, especially for metabolic aging. Acetate is more abundant but generally has broader and more moderate effects; still important, especially as a substrate and signaling molecule.

    • Anti-Inflammatory & Immune Modulation

      Chronic inflammation accelerates aging; these pathways reduce inflammatory markers. Bile acids are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Tryptophan-derived indoles are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Polyamines offer both immunomodulatory and cell-protective benefits, especially in aging tissue. LPS and ammonia detox are supportive pathways—critical but more indirect in their effects.

    • Energy Metabolism & Mitochondrial Health

      Efficient energy metabolism supports cellular function, reduces oxidative stress, and enhances lifespan. TCA cycle and ETC dominate due to their centrality in mitochondrial health, bioenergetics, and ROS control — all of which are strongly linked to aging processes. Fat oxidation (FAO) supports metabolic flexibility, ketogenesis, and fasting states — overlapping with caloric restriction benefits. BCAA metabolism is double-edged: essential for mitochondrial function but excessive levels may promote mTOR activation and insulin resistance — balance is critical.

    • Cellular Repair, DNA Protection & Autophagy

      These pathways regulate DNA repair, cellular stress resistance, and autophagy, essential for longevity. Methionine / glutathione gets top weight for direct protection against oxidative stress, a primary driver of DNA damage. NAD⁺ biosynthesis is central to sirtuin-driven longevity mechanisms and DNA repair. Folate supports DNA stability but has more indirect or cofactor-like effects compared to the above.

    • Caloric Restriction & Fasting Mimicry

      Certain pathways mimic the benefits of fasting and caloric restriction, which are linked to lifespan extension.

    Targeted Recommendations

    The module "Longevity & Healthy Aging" provides you with targeted nuttrition recommendations. Targeted not only on your unique gut microbiome but also targeted on the metabolic pathways that, according to the latest scientific publications, are important for Longevity & Healthy Aging.

    • Personalized on the DNA of your own Gut Microbiome

      Receive nutrition recommendations that according to our self-learning algorithms and our large customer database have the highest impact on your own unique gut microbiome.

    • Approved by our Dieticians

      We use Responsible A.I. techniques and built an algorithm that uses both our own proprietary databases but also the knowledge and experience of our strong dietician team.

    • Actionable

      Nutrition recommendations that you can just buy in your local supermarket. For your convenience, we also provide daily dosage recommendations.

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    Focus on your Biological Age and support Longevity & Healthy Aging - Order the gut test that:

    • Provides a score between 0 and 100 of how your gut microbiome composition is optimized for Biological Age / Longevity / Healthy Aging
    • Provides detailed insight in how you rank for each of the microbial metabolic pathways that have been linked to Biological Age / Longevity / Healthy Aging according to the latest scientific publications
    • Uses a cutting-edge and science-based DNA technology
    • Provides you with nutritional and supplement recommendations based on your microbial results that are specifically optimized to lower your Biological Age and support Longevity & Healthy Aging
    • Is developed by an expert team of dieticians, specialists, and scientists to offer you the most accurate gut microbiome analysis
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    How can InnerBuddies support in reducing your Biological Age and supporting Longevity & Healthy Aging?

    • Improved Digestive Health

      Optimizing the gut microbiome enhances digestion and nutrient absorption, ensuring the body gets vital vitamins and minerals necessary for cellular repair and maintenance, which supports overall health and slows biological aging.

    • Reduced Inflammation

      A balanced gut microbiome helps reduce chronic systemic inflammation—a major driver of aging and age-related diseases—thereby protecting tissues and organs and promoting healthy aging.

    • Enhanced Immune Function

      Gut health directly influences the immune system. Strengthening the microbiome boosts immunity, lowering the risk of infections and age-related immune decline, contributing to longevity.

    • Mental Health and Cognitive Function

      The gut-brain axis connects gut health with brain function. A healthy microbiome can improve mood, reduce anxiety, and support cognitive health, helping maintain mental sharpness with age.

    • Metabolic Health and Weight Management

      Microbiome-based nutrition helps regulate metabolism and blood sugar levels, reducing risks for diabetes and cardiovascular disease, which are linked to accelerated aging.

    • Antioxidant Support and Cellular Repair

      Supplements tailored to the gut microbiome can enhance antioxidant activity and promote cellular repair processes, protecting DNA from damage and slowing biological aging.