NAD⁺ and Sirtuin Pathways in Women’s Health: Advancing Longevity and Healthy Aging in France

    innerbuddies gut microbiome testing

    Women’s Health at the Nexus of NAD⁺ and Sirtuin Pathways: Advancing Longevity and Healthy Aging

    NAD⁺ and Sirtuin Pathways in Women’s Health: Advancing Longevity and Healthy Aging in France

    Why NAD⁺ and Sirtuins matter for women’s healthy aging

    At the forefront of longevity science, nicotinamide adenine dinucleotide (NAD⁺) and the sirtuin pathways help coordinate cellular energy production, mitochondrial function, DNA maintenance, and epigenetic signaling. Emerging research suggests these mechanisms may support women’s health across key systems—metabolic, cardiovascular, cognitive, bone, and skin—contributing to more resilient aging. By nourishing cellular defense and repair processes, optimizing NAD⁺ and sirtuin activity aligns with evidence-informed strategies for healthy aging and longevity in France.

    France’s lifestyle and research landscape for longevity

    France offers a distinctive backdrop where culinary traditions, active living, and prevention-oriented care intersect with innovation in aging science. Patterns such as balanced meals, regular walking or cycling, and polyphenol-rich foods (e.g., grapes, cocoa) are often discussed in relation to cellular metabolism and oxidative balance, factors connected to NAD⁺ dynamics and sirtuin signaling. In parallel, French and European research initiatives are exploring biomarkers of NAD metabolism, circadian biology, and women’s metabolic wellness—advancing a rigorous, translational view of longevity and healthy aging in France.

    Key focus areas across the female lifespan

    From the reproductive years through peri- and post-menopause, maintaining cellular resilience is central to women’s health in France. Areas of interest include metabolic flexibility, cardiovascular wellness, cognitive vitality, bone strength, and skin quality—domains where NAD⁺ availability and sirtuin pathways are actively studied. Evidence-informed lifestyle foundations—nutrient-dense eating, consistent sleep and daylight exposure, stress management, and a blend of aerobic and resistance activity—are frequently highlighted as supportive of cellular energy and circadian-aligned signaling. For personalized guidance, women can consult qualified professionals to integrate NAD⁺- and sirtuin-aware strategies into comprehensive longevity and healthy aging plans.

    Order a test! Order annual subscription with 2 or 3 tests!
    innerbuddies gut microbiome testing

    Translating NAD⁺ and Sirtuin Science into Women‑Centered Strategies in France

    Metabolic and Mitochondrial Support

    For everyday nutrition in France, patterns that stabilize glucose and supply polyphenols can help nurture cellular energy linked to NAD⁺ and sirtuin pathways. Emphasize vegetables, legumes, seafood, whole grains, extra‑virgin olive oil, and polyphenol‑rich foods like berries, cocoa, and grapes—an approach aligned with mitochondrial efficiency and oxidative balance. Including niacin‑containing foods (e.g., poultry, tuna, mushrooms, peanuts) supports the body’s NAD salvage processes, while circadian‑aligned meal timing—earlier, regular meals and a consistent eating window—may further coordinate metabolic signals under study in women’s healthy aging.

    Cardiovascular and Cognitive Resilience

    Active transport common in French cities—walking, cycling, stair climbing—paired with two to three weekly resistance sessions can engage pathways associated with SIRT1/SIRT3, vascular function, and mitochondrial biogenesis. Consistent sleep and morning daylight exposure help anchor circadian rhythms that interface with NAD⁺ dynamics and neurocognitive performance. Gentle stress‑reduction practices (breathwork, brief outdoor breaks, community connection) complement aerobic training, supporting autonomic balance that underpins heart‑brain longevity.

    Bone and Skin Vitality Across Life Stages

    Across peri‑ and post‑menopause, strength training and impact exercise (as individually appropriate) help maintain bone mineral density while interacting with energy‑sensing pathways that include sirtuins. Protein adequacy, calcium, vitamin D, and vitamin K2 from fermented foods, alongside colorful produce for antioxidants, can support collagen, dermal elasticity, and DNA maintenance relevant to skin aging. Daily photoprotection, quality sleep, and hydration align with cellular defense mechanisms where NAD⁺ availability and epigenetic signaling intersect with visible skin and skeletal health.

    Personalization, Metrics, and the French Research Landscape

    Women in France can collaborate with qualified professionals to tailor programs that respect individual biology, life stage, and preferences—integrating activity plans, nutrition, sleep regularity, and stress care with an eye to NAD⁺ and sirtuin science. Wearables and simple logs (sleep timing, step counts, mood, energy) provide feedback loops, while biomarkers of NAD metabolism and circadian biology remain an active research frontier in French and European consortia. This translational ecosystem supports evidence‑informed, ethical longevity strategies for women’s health in France, prioritizing sustainable habits that compound cellular resilience over time.

    Women's Health in Germany: NAD⁺ and Sirtuin Pathways Shaping Longevity & Healthy Aging NAD⁺ and Sirtuin Pathways in Women’s Health in Greece: Advancing Longevity and Healthy Aging

    Read more: NAD⁺ & Sirtuin Pathways for Women’s Longevity in France

    View more articles

    Get started with Longevity & Healthy Aging in 7 easy steps!

    • 1. Purchase a kit & create an account.

      Do not forget to buy the personalized nutrition advice and the 3-month Noory subscription to get maximum benefit for Longevity & Healthy Aging.

    • 2. Fill in 3 day food diary & survey

      In the survey select "Longevity & Healthy Aging" as your preferred target group. One FREE target group is included with every testkit.

    • 3. Take a stool sample

      And send it back in the return envelope with a prepaid return label. The return logistics and the laboratory process will generally take 3 to 4 weeks.

    • 4. View your results

      Once your results are uploaded and ready, you will receive an email. Login your dashboard to view all analysis results and recommendations. If you also included the nutrition advice and/or the 3-month Noory subscription in your purchase, these will also be available in your dashboard.

    • food recipe platform

      5. Noory platform

      If you bought the 3-month Noory subscription, you will receive direct access to personalized food recipes and meal plans on the Noory platform which AUTOMATICALLY take into account your gut microbiome nutrition advice, your allergies, intolerances and nutritional targets.

      Have ultimate real-time flexibility to choose the food recipes that you prefer to cook and eat. Accessible through desktop or mobile device.

    • health professional

      6. Link your Healthcare Professional (HCP) (optional)

      Both InnerBuddies and Noory are able to provide FREE access to the platform to your healthcare professional. But we need your EXPLICIT consent to do so given all privacy and health regulations. In the InnerBuddies platform you can also download all report sections in PDF format for sharing.

      Noory can also provide HCP access through NooryMed, a remote monitoring platform built for HCP's that allows sharing symptoms, food tracking and also takes into account Food - Drug interactions.

    • retest your gut health

      7. Retest your Gut Microbiome

      After your 3-month Noory subscription has ended, you can perform a new gut microbiome test and hopefully see the desired improvements in your test results. A new gut test will also update your nutrition recommendations and nutritional targets to the Noory platform so that you can start another 3-month improvement process. You can also select a new target group in the InnerBuddies platform if you want to set different objectives for the new 3-month period.

    The InnerBuddies module "Longevity & Healthy Aging" gives you insight in:

    • Gut Microbiome & Short-Chain Fatty Acids (SCFAs)

      SCFAs contribute to anti-inflammation, gut health, and metabolic regulation, all linked to longevity. SCFA's functions as the base mechanism for the other categories. Butyrate gets high weight because of its robust evidence base in inflammation control, gut barrier integrity, and mitochondrial health — all critical for longevity. Propionate pathways are also key, especially for metabolic aging. Acetate is more abundant but generally has broader and more moderate effects; still important, especially as a substrate and signaling molecule.

    • Anti-Inflammatory & Immune Modulation

      Chronic inflammation accelerates aging; these pathways reduce inflammatory markers. Bile acids are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Tryptophan-derived indoles are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Polyamines offer both immunomodulatory and cell-protective benefits, especially in aging tissue. LPS and ammonia detox are supportive pathways—critical but more indirect in their effects.

    • Energy Metabolism & Mitochondrial Health

      Efficient energy metabolism supports cellular function, reduces oxidative stress, and enhances lifespan. TCA cycle and ETC dominate due to their centrality in mitochondrial health, bioenergetics, and ROS control — all of which are strongly linked to aging processes. Fat oxidation (FAO) supports metabolic flexibility, ketogenesis, and fasting states — overlapping with caloric restriction benefits. BCAA metabolism is double-edged: essential for mitochondrial function but excessive levels may promote mTOR activation and insulin resistance — balance is critical.

    • Cellular Repair, DNA Protection & Autophagy

      These pathways regulate DNA repair, cellular stress resistance, and autophagy, essential for longevity. Methionine / glutathione gets top weight for direct protection against oxidative stress, a primary driver of DNA damage. NAD⁺ biosynthesis is central to sirtuin-driven longevity mechanisms and DNA repair. Folate supports DNA stability but has more indirect or cofactor-like effects compared to the above.

    • Caloric Restriction & Fasting Mimicry

      Certain pathways mimic the benefits of fasting and caloric restriction, which are linked to lifespan extension.

    Targeted Recommendations

    The module "Longevity & Healthy Aging" provides you with targeted nuttrition recommendations. Targeted not only on your unique gut microbiome but also targeted on the metabolic pathways that, according to the latest scientific publications, are important for Longevity & Healthy Aging.

    • Personalized on the DNA of your own Gut Microbiome

      Receive nutrition recommendations that according to our self-learning algorithms and our large customer database have the highest impact on your own unique gut microbiome.

    • Approved by our Dieticians

      We use Responsible A.I. techniques and built an algorithm that uses both our own proprietary databases but also the knowledge and experience of our strong dietician team.

    • Actionable

      Nutrition recommendations that you can just buy in your local supermarket. For your convenience, we also provide daily dosage recommendations.

    innerbuddies gut microbiome testing

    Focus on your Biological Age and support Longevity & Healthy Aging - Order the gut test that:

    • Provides a score between 0 and 100 of how your gut microbiome composition is optimized for Biological Age / Longevity / Healthy Aging
    • Provides detailed insight in how you rank for each of the microbial metabolic pathways that have been linked to Biological Age / Longevity / Healthy Aging according to the latest scientific publications
    • Uses a cutting-edge and science-based DNA technology
    • Provides you with nutritional and supplement recommendations based on your microbial results that are specifically optimized to lower your Biological Age and support Longevity & Healthy Aging
    • Is developed by an expert team of dieticians, specialists, and scientists to offer you the most accurate gut microbiome analysis
    Start your journey!

    How can InnerBuddies support in reducing your Biological Age and supporting Longevity & Healthy Aging?

    • Improved Digestive Health

      Optimizing the gut microbiome enhances digestion and nutrient absorption, ensuring the body gets vital vitamins and minerals necessary for cellular repair and maintenance, which supports overall health and slows biological aging.

    • Reduced Inflammation

      A balanced gut microbiome helps reduce chronic systemic inflammation—a major driver of aging and age-related diseases—thereby protecting tissues and organs and promoting healthy aging.

    • Enhanced Immune Function

      Gut health directly influences the immune system. Strengthening the microbiome boosts immunity, lowering the risk of infections and age-related immune decline, contributing to longevity.

    • Mental Health and Cognitive Function

      The gut-brain axis connects gut health with brain function. A healthy microbiome can improve mood, reduce anxiety, and support cognitive health, helping maintain mental sharpness with age.

    • Metabolic Health and Weight Management

      Microbiome-based nutrition helps regulate metabolism and blood sugar levels, reducing risks for diabetes and cardiovascular disease, which are linked to accelerated aging.

    • Antioxidant Support and Cellular Repair

      Supplements tailored to the gut microbiome can enhance antioxidant activity and promote cellular repair processes, protecting DNA from damage and slowing biological aging.