How Your Gut Microbes Might Be Accelerating Aging: The Surprising Role of PAGln
1. Introduction – Why Your Gut Might Hold the Key to Aging When people think about aging, they usually picture... Read more
Phenylacetylglutamine: The Gut Microbe Metabolite That Could Shape Your Health
The gut microbe phenylacetylglutamine (PAGln) is a metabolite produced by gut bacteria when they break down the amino acid phenylalanine. As researchers uncover how PAGln shapes communication between the gut and other organs, people are beginning to see how this molecule may reflect overall wellness and risk patterns beyond digestion. Emerging evidence suggests PAGln levels are linked with heart health: higher PAGln has been associated with greater risk of adverse cardiovascular events in some studies, possibly through effects on platelet function and vascular signaling. In kidney health, PAGln can accumulate when kidney function declines, making it both a potential biomarker and a signal to watch as part of a broader wellness strategy. It’s important to note that associations do not prove causation, but PAGln remains a compelling example of how the gut microbiome may influence organ systems. InnerBuddies offers a white-label Gut Health Operating System that can help you explore molecules like PAGln as part of a broader health picture. The platform includes a Gut Microbiome Health Index (0–100) based on an exclusive IP deal with EAFIT University in Colombia, giving a standardized snapshot of microbiome health. You can compare your top 40 bacteria abundances to a healthy cohort, and examine bacterial functions across categories, labeled positive or negative, to see where you stand on pathways relevant to wellness and disease risk, including those that may influence PAGln production. Target Group analysis lets you dive into how different populations—such as those focused on Healthy Aging, Endurance Sport, or Skin & Hair Health—score on metabolically important pathways. And with personalized nutrition advice derived from your 3-day food diaries and stool data, you get diet guidance tailored to your unique gut microbiome, plus personalized probiotics and prebiotics recommendations to fit your goals. Learn more about our test and how it works on our product page: InnerBuddies microbiome test. Whether you are a consumer seeking a direct-to-you gut test or a business wanting to offer a premium gut health solution, InnerBuddies has you covered. Our modular platform powers consumer-ready tests and white-labeled solutions for partners, and the same capabilities are available for individual customers through the InnerBuddies Gut Health Membership: InnerBuddies Gut Health Membership. If you’re a company exploring a collaboration, visit our B2B page to learn how to become a partner: InnerBuddies B2B Partner Page.