NAD⁺ & Sirtuin Pathway Clinics for Longevity & Healthy Aging

    innerbuddies gut microbiome testing

    NAD⁺ & Sirtuin Pathways: Molecular Keys to Longevity and Healthy Aging

    NAD⁺ & Sirtuin Pathway Clinics for Longevity & Healthy Aging

    Evidence‑informed cellular wellness for proactive aging

    Discover how our NAD⁺ & Sirtuin Pathway Clinics support longevity and healthy aging through an evidence‑informed, personalized approach to cellular health and metabolic wellness. By focusing on the body’s natural repair systems, mitochondrial function, and adaptive stress responses, we design thoughtful strategies to help maintain energy, clarity, and resilience as you age. Whether you’re exploring NAD⁺ therapy, interested in sirtuin pathway optimization, or seeking a comprehensive roadmap for proactive aging, our team prioritizes safety, transparency, and guidance grounded in current research.

    NAD⁺ is a vital coenzyme involved in cellular energy production, DNA maintenance, and signaling, while sirtuins are NAD⁺‑dependent proteins that help coordinate stress response, metabolic pathways, and genomic stability. Because NAD⁺ levels can decline with age, carefully structured programs that emphasize lifestyle foundations and clinically supervised options—such as nutrient optimization or NAD⁺‑supportive strategies—may help sustain cellular efficiency. We emphasize realistic expectations: evidence is evolving, individual results vary, and not every approach suits every person; decisions are made collaboratively with qualified clinicians.

    From thorough intake and appropriate lab review to individualized plans and continuous monitoring, our clinics deliver a cohesive experience for healthy longevity. Services can integrate sleep and stress coaching, movement planning, and nutrition guidance alongside any medical recommendations, with a safety‑first mindset and coordination with your primary‑care providers. Ready to start? Schedule a consultation to learn whether a NAD⁺ & sirtuin pathway program aligns with your goals. These services are not a substitute for urgent or primary care and are not intended to diagnose, treat, cure, or prevent any disease.

    Order a test! Order annual subscription with 2 or 3 tests!
    innerbuddies gut microbiome testing

    Personalizing Your NAD⁺ & Sirtuin Pathway Plan

    What to expect after your initial consultation

    Following your intake, our clinicians synthesize history, goals, and appropriate labs to map key domains of cellular wellness—including mitochondrial efficiency, redox balance, metabolic flexibility, and recovery capacity. We translate findings into a clear roadmap with staged priorities, measurable milestones, and safety guardrails. You’ll know exactly why each step is chosen, how it relates to NAD⁺ dynamics and sirtuin pathway signaling, and which indicators (energy, sleep quality, training response, focus) we’ll track to guide adjustments. Our approach is evidence‑informed, pragmatic, and tailored to your context—no hype, just transparent rationale and collaborative decision‑making.

    We reinforce foundations first. Expect guidance on circadian rhythm alignment, sleep architecture, and stress modulation, alongside nutrition strategies that emphasize protein distribution, micronutrient sufficiency, and polyphenol‑rich whole foods. Movement planning integrates resistance training, aerobic base (Zone 2), and strategic intensity for mitochondrial biogenesis—all scaled to your capacity. When appropriate, we may incorporate gentle hormetic practices (sauna, cold exposure, breathwork) to support adaptive resilience. These pillars are personalized to support metabolic wellness, autophagy/mitophagy balance, and healthy aging without overcomplication.

    When clinically appropriate, we discuss NAD⁺‑supportive options under supervision—such as monitored protocols or tailored precursor strategies—prioritizing comfort, gradual titration, and tolerance. We also explore behavior‑based levers that can influence sirtuin activity, like exercise timing and meal timing, applied cautiously and only when aligned with your medical profile. We emphasize realistic expectations and ongoing evidence appraisal: individual responses vary, data are evolving, and choices are made collaboratively with your care team to keep safety and clarity at the forefront.

    Progress is guided by continuous monitoring and iteration. We track practical outcomes (daytime energy, cognitive clarity, sleep metrics, recovery), review labs when indicated, and coordinate with your primary‑care providers for an integrated, safety‑first plan. You’ll receive concise updates, transparent risk‑benefit discussions, and alternatives if a given pathway isn’t the right fit. If you’re ready to explore a responsible, longevity-focused program rooted in cellular health and measurable habits, schedule a consultation to learn whether our NAD⁺ & sirtuin pathway clinic model aligns with your goals.

    Unlocking Longevity and Healthy Aging: NAD⁺ & Sirtuin Pathways in Older Adults Athletes and the NAD⁺ & Sirtuin Pathways: Pioneering Longevity and Healthy Aging in Modern Sports

    Find more details about NAD⁺ & Sirtuin Pathways in Clinics

    You can find more information on the related topics below.

    Read more: Clinics on NAD⁺ & Sirtuin Pathways for Longevity & Healthy Aging

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    Get started with Longevity & Healthy Aging in 7 easy steps!

    • 1. Purchase a kit & create an account.

      Do not forget to buy the personalized nutrition advice and the 3-month Noory subscription to get maximum benefit for Longevity & Healthy Aging.

    • 2. Fill in 3 day food diary & survey

      In the survey select "Longevity & Healthy Aging" as your preferred target group. One FREE target group is included with every testkit.

    • 3. Take a stool sample

      And send it back in the return envelope with a prepaid return label. The return logistics and the laboratory process will generally take 3 to 4 weeks.

    • 4. View your results

      Once your results are uploaded and ready, you will receive an email. Login your dashboard to view all analysis results and recommendations. If you also included the nutrition advice and/or the 3-month Noory subscription in your purchase, these will also be available in your dashboard.

    • food recipe platform

      5. Noory platform

      If you bought the 3-month Noory subscription, you will receive direct access to personalized food recipes and meal plans on the Noory platform which AUTOMATICALLY take into account your gut microbiome nutrition advice, your allergies, intolerances and nutritional targets.

      Have ultimate real-time flexibility to choose the food recipes that you prefer to cook and eat. Accessible through desktop or mobile device.

    • health professional

      6. Link your Healthcare Professional (HCP) (optional)

      Both InnerBuddies and Noory are able to provide FREE access to the platform to your healthcare professional. But we need your EXPLICIT consent to do so given all privacy and health regulations. In the InnerBuddies platform you can also download all report sections in PDF format for sharing.

      Noory can also provide HCP access through NooryMed, a remote monitoring platform built for HCP's that allows sharing symptoms, food tracking and also takes into account Food - Drug interactions.

    • retest your gut health

      7. Retest your Gut Microbiome

      After your 3-month Noory subscription has ended, you can perform a new gut microbiome test and hopefully see the desired improvements in your test results. A new gut test will also update your nutrition recommendations and nutritional targets to the Noory platform so that you can start another 3-month improvement process. You can also select a new target group in the InnerBuddies platform if you want to set different objectives for the new 3-month period.

    The InnerBuddies module "Longevity & Healthy Aging" gives you insight in:

    • Gut Microbiome & Short-Chain Fatty Acids (SCFAs)

      SCFAs contribute to anti-inflammation, gut health, and metabolic regulation, all linked to longevity. SCFA's functions as the base mechanism for the other categories. Butyrate gets high weight because of its robust evidence base in inflammation control, gut barrier integrity, and mitochondrial health — all critical for longevity. Propionate pathways are also key, especially for metabolic aging. Acetate is more abundant but generally has broader and more moderate effects; still important, especially as a substrate and signaling molecule.

    • Anti-Inflammatory & Immune Modulation

      Chronic inflammation accelerates aging; these pathways reduce inflammatory markers. Bile acids are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Tryptophan-derived indoles are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Polyamines offer both immunomodulatory and cell-protective benefits, especially in aging tissue. LPS and ammonia detox are supportive pathways—critical but more indirect in their effects.

    • Energy Metabolism & Mitochondrial Health

      Efficient energy metabolism supports cellular function, reduces oxidative stress, and enhances lifespan. TCA cycle and ETC dominate due to their centrality in mitochondrial health, bioenergetics, and ROS control — all of which are strongly linked to aging processes. Fat oxidation (FAO) supports metabolic flexibility, ketogenesis, and fasting states — overlapping with caloric restriction benefits. BCAA metabolism is double-edged: essential for mitochondrial function but excessive levels may promote mTOR activation and insulin resistance — balance is critical.

    • Cellular Repair, DNA Protection & Autophagy

      These pathways regulate DNA repair, cellular stress resistance, and autophagy, essential for longevity. Methionine / glutathione gets top weight for direct protection against oxidative stress, a primary driver of DNA damage. NAD⁺ biosynthesis is central to sirtuin-driven longevity mechanisms and DNA repair. Folate supports DNA stability but has more indirect or cofactor-like effects compared to the above.

    • Caloric Restriction & Fasting Mimicry

      Certain pathways mimic the benefits of fasting and caloric restriction, which are linked to lifespan extension.

    Targeted Recommendations

    The module "Longevity & Healthy Aging" provides you with targeted nuttrition recommendations. Targeted not only on your unique gut microbiome but also targeted on the metabolic pathways that, according to the latest scientific publications, are important for Longevity & Healthy Aging.

    • Personalized on the DNA of your own Gut Microbiome

      Receive nutrition recommendations that according to our self-learning algorithms and our large customer database have the highest impact on your own unique gut microbiome.

    • Approved by our Dieticians

      We use Responsible A.I. techniques and built an algorithm that uses both our own proprietary databases but also the knowledge and experience of our strong dietician team.

    • Actionable

      Nutrition recommendations that you can just buy in your local supermarket. For your convenience, we also provide daily dosage recommendations.

    innerbuddies gut microbiome testing

    Focus on your Biological Age and support Longevity & Healthy Aging - Order the gut test that:

    • Provides a score between 0 and 100 of how your gut microbiome composition is optimized for Biological Age / Longevity / Healthy Aging
    • Provides detailed insight in how you rank for each of the microbial metabolic pathways that have been linked to Biological Age / Longevity / Healthy Aging according to the latest scientific publications
    • Uses a cutting-edge and science-based DNA technology
    • Provides you with nutritional and supplement recommendations based on your microbial results that are specifically optimized to lower your Biological Age and support Longevity & Healthy Aging
    • Is developed by an expert team of dieticians, specialists, and scientists to offer you the most accurate gut microbiome analysis
    Start your journey!

    How can InnerBuddies support in reducing your Biological Age and supporting Longevity & Healthy Aging?

    • Improved Digestive Health

      Optimizing the gut microbiome enhances digestion and nutrient absorption, ensuring the body gets vital vitamins and minerals necessary for cellular repair and maintenance, which supports overall health and slows biological aging.

    • Reduced Inflammation

      A balanced gut microbiome helps reduce chronic systemic inflammation—a major driver of aging and age-related diseases—thereby protecting tissues and organs and promoting healthy aging.

    • Enhanced Immune Function

      Gut health directly influences the immune system. Strengthening the microbiome boosts immunity, lowering the risk of infections and age-related immune decline, contributing to longevity.

    • Mental Health and Cognitive Function

      The gut-brain axis connects gut health with brain function. A healthy microbiome can improve mood, reduce anxiety, and support cognitive health, helping maintain mental sharpness with age.

    • Metabolic Health and Weight Management

      Microbiome-based nutrition helps regulate metabolism and blood sugar levels, reducing risks for diabetes and cardiovascular disease, which are linked to accelerated aging.

    • Antioxidant Support and Cellular Repair

      Supplements tailored to the gut microbiome can enhance antioxidant activity and promote cellular repair processes, protecting DNA from damage and slowing biological aging.