Clinics in Cellular Senescence & Inflammaging: Pioneering Pathways to Longevity and Healthy Aging

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    Cellular Senescence & Inflammaging: Unlocking Pathways to Longevity & Healthy Aging

    Clinics in Cellular Senescence & Inflammaging: Pioneering Pathways to Longevity and Healthy Aging

    Understanding the biology behind accelerated aging

    Our clinics focus on the root drivers of biological aging by addressing cellular senescence and the chronic, low-grade inflammaging that can impair tissue function over time. By evaluating how senescent cells and the senescence-associated secretory phenotype (SASP) influence resilience, we translate longevity science into practical care. This evidence-informed approach supports healthy aging through strategies that help preserve mobility, cognition, and metabolic balance—key pillars of a longer, more vibrant healthspan.

    Personalized longevity pathways grounded in data

    We combine advanced aging biomarkers with comprehensive lifestyle assessment to create tailored plans for each individual. Multi-omic insights, immune and metabolic profiling, and functional testing help map out targeted interventions. Programs may include nutrition optimization, supervised exercise, sleep and stress strategies, and other supportive measures. Where appropriate and under clinical supervision, we consider emerging tools such as senolytics and senomorphics, reflecting the latest research on cellular senescence and inflammaging while prioritizing safety and measurable outcomes.

    A proactive, collaborative model for healthy longevity

    Designed for those seeking longevity, performance, and prevention, our clinics emphasize transparency, education, and iterative care. Regular re-testing and outcomes tracking guide data-driven refinements, while collaboration with your existing healthcare team promotes coordinated, whole-person support. By systematically reducing inflammatory burden and bolstering repair pathways, we aim to extend your healthy lifespan. Discover how a focused strategy on cellular senescence and inflammaging can keep you stronger, sharper, and active for longer.

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    From Mechanism to Measurable Impact: Deepening the Longevity Care Pathway

    Precision evaluation to map your inflammaging and senescence burden

    We begin with a rigorous, data-rich profile of your cellular senescence and inflammaging status, integrating epigenetic-age signatures, immune and cytokine panels, cardiometabolic markers, and body-composition and fitness metrics. Advanced aging biomarkers and multi-omic readouts illuminate SASP activity, mitochondrial resilience, and recovery capacity, enabling precise stratification of risk and opportunity. This 360-degree baseline anchors individualized goals and establishes clear benchmarks for healthy aging progress.

    Interventions that build capacity across metabolism, brain, and musculoskeletal health

    Programs in our longevity clinics prioritize foundational levers—targeted nutrition, structured exercise (strength, aerobic, and power), sleep optimization, stress modulation, and microbiome support—to help reduce inflammatory load and improve metabolic flexibility. Evidence-aligned strategies encourage autophagy and cellular repair, bolster mitochondrial function, and support immune balance, aiming to support mobility, cognitive resilience, and sustained energy. Each protocol is tailored to your context, preferences, and readiness, emphasizing safety, adherence, and real-world outcomes.

    Thoughtful use of senescence-modulating tools under clinical oversight

    For select candidates and when appropriate, we may consider adjuncts that target senescent cells and the SASP—such as senolytics and senomorphics—within a monitored, time-bounded framework. Any such approach is grounded in current research, careful risk–benefit review, and objective monitoring (labs, functional testing, and symptom tracking) to safeguard against overuse and ensure measurable value. The emphasis remains on sustainable, lifestyle-centered care with pharmacologic or nutraceutical options used judiciously.

    Continuous monitoring, transparent reporting, and adaptive optimization

    We operationalize healthy lifespan gains through regular re-testing, outcomes dashboards, and shared decision-making. Key performance indicators—grip strength, gait speed, VO2 max proxies, glycemic control, inflammatory markers, sleep quality, and cognitive screening—guide iterative refinements that keep you on track. This proactive, collaborative model keeps your plan aligned with evolving evidence and your goals, turning longevity science into reliable, day-to-day practice.

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    Find more details about Cellular Senescence & Inflammaging in Clinics

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    Get started with Longevity & Healthy Aging in 7 easy steps!

    • 1. Purchase a kit & create an account.

      Do not forget to buy the personalized nutrition advice and the 3-month Noory subscription to get maximum benefit for Longevity & Healthy Aging.

    • 2. Fill in 3 day food diary & survey

      In the survey select "Longevity & Healthy Aging" as your preferred target group. One FREE target group is included with every testkit.

    • 3. Take a stool sample

      And send it back in the return envelope with a prepaid return label. The return logistics and the laboratory process will generally take 3 to 4 weeks.

    • 4. View your results

      Once your results are uploaded and ready, you will receive an email. Login your dashboard to view all analysis results and recommendations. If you also included the nutrition advice and/or the 3-month Noory subscription in your purchase, these will also be available in your dashboard.

    • food recipe platform

      5. Noory platform

      If you bought the 3-month Noory subscription, you will receive direct access to personalized food recipes and meal plans on the Noory platform which AUTOMATICALLY take into account your gut microbiome nutrition advice, your allergies, intolerances and nutritional targets.

      Have ultimate real-time flexibility to choose the food recipes that you prefer to cook and eat. Accessible through desktop or mobile device.

    • health professional

      6. Link your Healthcare Professional (HCP) (optional)

      Both InnerBuddies and Noory are able to provide FREE access to the platform to your healthcare professional. But we need your EXPLICIT consent to do so given all privacy and health regulations. In the InnerBuddies platform you can also download all report sections in PDF format for sharing.

      Noory can also provide HCP access through NooryMed, a remote monitoring platform built for HCP's that allows sharing symptoms, food tracking and also takes into account Food - Drug interactions.

    • retest your gut health

      7. Retest your Gut Microbiome

      After your 3-month Noory subscription has ended, you can perform a new gut microbiome test and hopefully see the desired improvements in your test results. A new gut test will also update your nutrition recommendations and nutritional targets to the Noory platform so that you can start another 3-month improvement process. You can also select a new target group in the InnerBuddies platform if you want to set different objectives for the new 3-month period.

    The InnerBuddies module "Longevity & Healthy Aging" gives you insight in:

    • Gut Microbiome & Short-Chain Fatty Acids (SCFAs)

      SCFAs contribute to anti-inflammation, gut health, and metabolic regulation, all linked to longevity. SCFA's functions as the base mechanism for the other categories. Butyrate gets high weight because of its robust evidence base in inflammation control, gut barrier integrity, and mitochondrial health — all critical for longevity. Propionate pathways are also key, especially for metabolic aging. Acetate is more abundant but generally has broader and more moderate effects; still important, especially as a substrate and signaling molecule.

    • Anti-Inflammatory & Immune Modulation

      Chronic inflammation accelerates aging; these pathways reduce inflammatory markers. Bile acids are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Tryptophan-derived indoles are among the most potent microbial immunomodulators with systemic relevance (gut-liver-brain axis, mucosal immunity). Polyamines offer both immunomodulatory and cell-protective benefits, especially in aging tissue. LPS and ammonia detox are supportive pathways—critical but more indirect in their effects.

    • Energy Metabolism & Mitochondrial Health

      Efficient energy metabolism supports cellular function, reduces oxidative stress, and enhances lifespan. TCA cycle and ETC dominate due to their centrality in mitochondrial health, bioenergetics, and ROS control — all of which are strongly linked to aging processes. Fat oxidation (FAO) supports metabolic flexibility, ketogenesis, and fasting states — overlapping with caloric restriction benefits. BCAA metabolism is double-edged: essential for mitochondrial function but excessive levels may promote mTOR activation and insulin resistance — balance is critical.

    • Cellular Repair, DNA Protection & Autophagy

      These pathways regulate DNA repair, cellular stress resistance, and autophagy, essential for longevity. Methionine / glutathione gets top weight for direct protection against oxidative stress, a primary driver of DNA damage. NAD⁺ biosynthesis is central to sirtuin-driven longevity mechanisms and DNA repair. Folate supports DNA stability but has more indirect or cofactor-like effects compared to the above.

    • Caloric Restriction & Fasting Mimicry

      Certain pathways mimic the benefits of fasting and caloric restriction, which are linked to lifespan extension.

    Targeted Recommendations

    The module "Longevity & Healthy Aging" provides you with targeted nuttrition recommendations. Targeted not only on your unique gut microbiome but also targeted on the metabolic pathways that, according to the latest scientific publications, are important for Longevity & Healthy Aging.

    • Personalized on the DNA of your own Gut Microbiome

      Receive nutrition recommendations that according to our self-learning algorithms and our large customer database have the highest impact on your own unique gut microbiome.

    • Approved by our Dieticians

      We use Responsible A.I. techniques and built an algorithm that uses both our own proprietary databases but also the knowledge and experience of our strong dietician team.

    • Actionable

      Nutrition recommendations that you can just buy in your local supermarket. For your convenience, we also provide daily dosage recommendations.

    innerbuddies gut microbiome testing

    Focus on your Biological Age and support Longevity & Healthy Aging - Order the gut test that:

    • Provides a score between 0 and 100 of how your gut microbiome composition is optimized for Biological Age / Longevity / Healthy Aging
    • Provides detailed insight in how you rank for each of the microbial metabolic pathways that have been linked to Biological Age / Longevity / Healthy Aging according to the latest scientific publications
    • Uses a cutting-edge and science-based DNA technology
    • Provides you with nutritional and supplement recommendations based on your microbial results that are specifically optimized to lower your Biological Age and support Longevity & Healthy Aging
    • Is developed by an expert team of dieticians, specialists, and scientists to offer you the most accurate gut microbiome analysis
    Start your journey!

    How can InnerBuddies support in reducing your Biological Age and supporting Longevity & Healthy Aging?

    • Improved Digestive Health

      Optimizing the gut microbiome enhances digestion and nutrient absorption, ensuring the body gets vital vitamins and minerals necessary for cellular repair and maintenance, which supports overall health and slows biological aging.

    • Reduced Inflammation

      A balanced gut microbiome helps reduce chronic systemic inflammation—a major driver of aging and age-related diseases—thereby protecting tissues and organs and promoting healthy aging.

    • Enhanced Immune Function

      Gut health directly influences the immune system. Strengthening the microbiome boosts immunity, lowering the risk of infections and age-related immune decline, contributing to longevity.

    • Mental Health and Cognitive Function

      The gut-brain axis connects gut health with brain function. A healthy microbiome can improve mood, reduce anxiety, and support cognitive health, helping maintain mental sharpness with age.

    • Metabolic Health and Weight Management

      Microbiome-based nutrition helps regulate metabolism and blood sugar levels, reducing risks for diabetes and cardiovascular disease, which are linked to accelerated aging.

    • Antioxidant Support and Cellular Repair

      Supplements tailored to the gut microbiome can enhance antioxidant activity and promote cellular repair processes, protecting DNA from damage and slowing biological aging.