Zonulin Levels: What Your Gut Permeability Says About Health


Zonulin levels are a key window into your gut permeability. Zonulin is a regulator of tight junctions in the intestinal lining, and rising zonulin levels typically signal a leakier gut barrier. When the barrier is compromised, larger molecules can enter the bloodstream, which may contribute to inflammation, food sensitivities, and fatigue. Understanding zonulin levels helps you connect gut health with overall well-being and explains why dietary and lifestyle changes can have a meaningful impact on your energy, skin, and immune function. To interpret zonulin levels accurately, you need a broader picture of the gut ecosystem. InnerBuddies offers a white-label Gut Health Operating System that companies can use to power their gut microbiome testing products. The platform includes a Gut Microbiome Health Index (0–100) based on an exclusive IP deal with EAFIT University in Colombia, giving you a single score for overall gut health. It also presents a top 40 bacteria abundances with benchmarking against a healthy cohort, and detailed bacterial functions categorized as positive or negative so you can see how your profile stacks up on each functional pathway. With Target Group analysis for topics like Healthy Aging, Endurance Sport, and Skin & Hair Health, you get focused insights, while personalized nutrition advice and personalized probiotics and prebiotics suggestions tailor plans to your unique gut microbiome. Learn more about how this integrates with zonulin levels to guide decisions on gut barrier health. Because zonulin levels are just one facet of gut health, InnerBuddies also brings actionable steps: a 3-day food diary-driven approach that links diet to microbial responses, enabling truly personalized nutrition that can support barrier integrity. The same system can be delivered directly to consumers or via partners, with both consumer-grade options and a powerful B2B white-label solution. Explore the InnerBuddies microbiome test page to learn more about core testing, the gut health membership for ongoing guidance, or partner with InnerBuddies to bring a white-label offering to your audience: InnerBuddies microbiome test, InnerBuddies gut health membership, and InnerBuddies partner program. Practical steps to optimize zonulin levels and support gut barrier health begin with your daily choices. Prioritize a diverse, fiber-rich diet that feeds beneficial bacteria, include fermented foods to support lactobacilli and other helpful microbes, and incorporate polyphenol-rich plants such as berries, leafy greens, and spices. Balance your meals with adequate protein and healthy fats to stabilize blood sugar and reduce inflammatory triggers. Pair these changes with stress management, sufficient sleep, regular physical activity, and good hydration—lifestyle factors that influence gut permeability. If you want a guided, data-driven path, start with the InnerBuddies microbiome test to establish a baseline and then use the personalized nutrition and probiotic/prebiotic recommendations to support your gut barrier over time. You can also explore ongoing access to tailored insights through the InnerBuddies gut health membership, or connect with partners who offer the same white-label capabilities via the InnerBuddies partner program.