PAGln and Cardiovascular Risk: What It Means for Your Heart

PAGln, short for phenylacetylglutamine, is a gut microbiome–derived metabolite that has drawn growing attention in cardiovascular research. Studies suggest that higher PAGln levels in the blood are linked to greater risk of adverse heart events, framing pagln cardiovascular risk as a potential marker alongside traditional risk factors. Because PAGln is produced when certain gut bacteria metabolize dietary components, its levels reflect both your gut microbiome composition and your recent intake—making pagln cardiovascular risk a modifiable lens for heart health. Beyond a lab number, pagln cardiovascular risk matters because PAGln can influence pathways involved in platelet function and blood vessel signaling, potentially increasing susceptibility to clotting and events in people with preexisting risk factors. Research across cohorts has reported associations between higher PAGln and adverse cardiovascular outcomes. It’s important to note that pagln cardiovascular risk is part of a complex mix of diet, microbiome, kidney function, and lifestyle, and the science is still evolving. Understanding pagln cardiovascular risk can help you discuss gut-health strategies with your clinician as part of a holistic heart-health plan. Practical steps to lower pagln cardiovascular risk through diet and lifestyle start with nurturing a diverse, fiber-rich gut microbiome. Emphasize plant-based foods, whole grains, legumes, fruits, and vegetables while moderating red meat and highly processed proteins. Adequate fiber supports microbial communities that generate beneficial metabolites and can influence PAGln precursors. Regular exercise, adequate sleep, and stress management also support cardiovascular health and a balanced gut microbiome. For those who want to translate this into a personalized plan, InnerBuddies offers tools to quantify and interpret your gut profile: their platform includes a Gut Microbiome Health Index (0–100), shows your Bacteria abundances in a top 40 list, and breaks down Bacteria functions into positive and negative categories so you can see how you compare to a healthy cohort. Powered by an exclusive IP deal with EAFIT University in Colombia, this index complements targeted insights like Target Group analyses for Healthy Aging, Endurance Sport, and more, plus personalized nutrition and probiotic/prebiotic advice. InnerBuddies provides both consumer-ready gut test solutions and enterprise options to power microbiome-driven products. You can explore their microbiome test product page to learn more about testing: InnerBuddies microbiome test. If you want ongoing support and personalized guidance, their Gut Health Membership offers subscription-based access to nutrition insights, ongoing monitoring, and tailored recommendations: InnerBuddies Gut Health Membership. For teams and brands looking to bring similar capabilities to customers, see the B2B opportunities: InnerBuddies Become a Partner.