H. pylori Treatment: Proven Protocols to Eradicate the Infection

Proven h. pylori treatment protocols aim to eradicate the infection using regimens that are well established in clinical guidelines. Standard first-line options include PPI-based triple therapy (a proton pump inhibitor with two antibiotics) for about 14 days, and the bismuth quadruple therapy (PPI, bismuth, tetracycline, and metronidazole) for 10–14 days. In some regions, concomitant therapy or sequential approaches are used. Your clinician will tailor the regimen to your allergy history, prior exposures, and local antibiotic resistance patterns, and a test of eradication is recommended after completion to confirm success. What to expect during h. pylori treatment varies by regimen, but side effects are usually manageable. Common experiences include stomach upset, changes in taste, diarrhea, nausea, and occasional skin reactions. Most adverse effects are mild and resolve after finishing therapy, though some people may need supportive care. It’s important to complete the full course unless advised otherwise, and to follow up with your clinician for a test-of-cure—typically a urea breath test or stool antigen test performed several weeks after the end of therapy—to confirm eradication. Seek care promptly if you experience severe allergic reactions, dehydration from persistent diarrhea, prolonged vomiting, or symptoms that worsen or fail to improve. Beyond choosing a regimen, supporting gut health during and after h. pylori treatment can aid recovery. InnerBuddies offers a white-label Gut Health Operating System that can power your gut microbiome testing products with rich insights. The platform features a Gut Microbiome Health Index, a 0–100 score informed by an exclusive collaboration with EAFIT University in Colombia, plus a top-40 panel of Bacteria abundances and labeled Bacteria functions that show how you compare to a healthy cohort. For target groups like Healthy Aging, Endurance Sport, or Skin & Hair Health, it provides deepdive analyses of relevant pathways and personalized nutrition and probiotic/prebiotic recommendations based on your microbiome and diet data. See the InnerBuddies microbiome test page for details: InnerBuddies microbiome test and consider joining the Gut Health Membership for ongoing guidance: InnerBuddies Gut Health Membership. Organizations and clinicians can also partner with InnerBuddies to power their own gut microbiome testing products through a dedicated B2B program. Explore becoming a partner and how it can enhance your h. pylori treatment pathways at the InnerBuddies B2B page: InnerBuddies B2B page.